| TREATMENT
OF CHRONIC HEPATITIS C
Standard Therapy
Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic
non-A, non-B hepatitis with recombinant human alpha
interferon: A preliminary report. New Engl J Med 1986;
315:1575-1578.
Davis GL, Balart LA, Schiff ER, et al. Treatment of chronic
hepatitis C with recombinant interferon alpha: A multicenter
randomized, controlled trial. New Engl J Med 1989; 321:1501-1506.
Marcellin P, Boyer N, Giostra, et al. Recombinant human alpha-
interferon in patients with chronic non A non B hepatitis:
a multicenter randomized controlled trial from France.
Hepatology 1991; 13:393-397.
Causse x, Godinot H, Ouzan D, et al. Comparison of 1 or 3
MU of interferon alfa-2b and placebo in patients with
chronic non-A non-B hepatitis. Gastroenterology 1991;
101:497-502.
TinŽ F, Margin S, Craxi A, Pagliaro L. Interferon for non-A,
non- B chronic Hepatitis: a meta-analysis of randomized
clinical trials. J Hepatol 1991; 13:192-199.
Alternative regimens: Higher dose, Longer duration
Beloqui O, Prieto J, Suarez M, Gil B, Qian CH, Garcia N, Civeira
MP. N-acetyl cysteine enhances the response to interferon-alpha
in chronic hepatitis C: a pilot study. J Interferon
Res 1993; 13:279-282.
Kakumu S, Yoshioka K, Wakita T, Ishikawa T, Takayanagi M,
Higashi Y. A pilot study of ribavirin and interferon
beta for the treatment of chronic hepatitis C. Gastroenterology
1993; 105:507- 512.
Liaw YF, Sheen IS, Lin SM, Chen TJ, Chu CM. Effects of prednisolone
pretreatment in interferon alfa therapy for patients with
chronic non-A, non-B (C) hepatitis. Liver 1993; 13:46-50.
Alternatives to Interferon
Camps J, Garcia N, Riezu-Boj JI, Civiera MP, Prieto J. Ribavirin
in the treatment of chronic hepatitis C unresponsive
to alfa interferon. J Hepatol 1993; 19:408-412.
Bodenheimer HC, Lindsay K, Davis GL, et al. Ribavirin treatment
of chronic hepatitis C. Hepatology 1994; 20:(abstract
in press).
SPECIAL PATIENT GROUPS
Decompensated Cirrhosis
Dimopoulou M, Fafoutis K, Basiliou K, Ketikoglou J, Karvountzis
G. Interferon alfa-2a for decompensated liver disease
caused by wither chronic hepatitis B or C: preliminary
results of a pilot study. Gut 1993; 34 (suppl 2):S104-105.
HIV infected patients
Eyster ME, Diamondstone
LS, Lien JM, Ehmann WC, Quan S, Goedert JJ. The natural
history of hepatitis C virus infection in multitransfused
hemophiliacs: Effects of coinfection with human immunodeficiency
virus. Acquir Immune Defic Syndr 1993; 6:602.
Eyster ME, Fried MW, DiBisceglie AM, Goedert JJ. Increasing
HCV RNA levels in hemophiliacs: Relationship to HIV
infection and liver disease. Blood 1994; (in press).
Boyer N, Marcellin P. Degott C, Degos F, Saimot AG, Erlinger
S, Benhamou JP. Recombinant interferon-alpha for chronic
hepatitis C in patients positive for antibody to human
immunodeficiency virus. J Infect Dis 1992; 165:723-726.
Hemophiliacs
Makis M, Preston FR, Triger DR, Underwood JC, Westlake L,
Adelman MI. A randomized controlled trial of recombinant
interferon-alpha in chronic hepatitis C in hemophiliacs.
Blood 1991; 78:1672-1677.
Transplant Recipients
Lim HL, Lau GK, Davis GL, Dolson DJ, Lau JYN. Cholestatic
hepatitis leading to hepatic failure in a patients with
organ- transmitted hepatitis C virus infection. Gastroenterology
1994; 106:248-251.
Ferrel LD, Wright TL, Roberts J, Ascher N, Lake J. Hepatitis
C viral infection in liver transplant recipients. Hepatology
1992; 16:865-876.
Wright HI, Gavaler JS, Van Thiel DH. Preliminary experience
with alpha-2b interferon therapy of viral hepatitis
in liver allograft recipients. Transplantation 1992;
53:121-124.
Asymptomatic Carriers
Naito M, Hayashi N, Hagiwara H, Hiram N, Kasahara A, Fusamato
H, Kamada T. Serum hepatitis C virus RNA quantity and
histological features of hepatitis C virus carriers
with persistently normal ALT levels. Hepatology 1994; 19:871-875.
Extrahepatic Disease
Lunel F, Musset L, Cacoub P, et al. Cryoglobulinemia in chronic
liver diseases: role of hepatitis C virus and liver
damage. Gastroenterology 1994; 106:1291-1300.
TREATMENT OF ACUTE HEPATITIS C
Viladomiu L, Genesca J, Estaban JI, et al. Interferon alpha
in acute posttransfusion hepatitis C: a randomized controlled
trial. Hepatology 1992; 15:767-769.
Omata M, Yokosuka O, Takano S et al. Resolution of acute hepatitis
C after therapy with natural beta interferon. Lancet
1991; 338:914-915.
Lampertico P, Rumi M, Romeo R, Craxi A, Soffrededini R, Biassoni
D, Colombo M. A multicenter randomized controlled trial
of recombinant interferon alpha-2b in patients with
acute transfusion- associated hepatitis C. Hepatology 1994;
19:19-22.
Tassopoulos NC, Koutelou MG, Papatheodoridis G, et al. Recombinant
human interferon alfa-2b treatment for acute non-A,
non-B hepatitis. Gut 1993; 34:S130-132.
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